While there are many different established treatments for cancer, there is no evidence that fenbendazole can cure it. In fact, the anthelmintic has never been tested in randomized clinical trials.
Interestingly, the treatment also disrupts autophagy and induces ferroptosis in colorectal cancer cells. Moreover, the drug blocks the growth of tumors through moderate microtubule disruption, p53 stabilization, and inhibition in glucose metabolism.
It kills parasites
Benzimidazoles are a class of drugs that bind beta-tubulin and disrupt microtubules. These drugs are used to kill worms, including roundworms, hookworms, whipworms, and some tapeworms in animals. These drugs are marketed in veterinary medicine under brand names like Pancur and Safe-Guard. Recently, they have been shown to be effective in killing cancer cells in laboratory studies. In addition, fenbendazole can also reduce drug resistance that often occurs during chemotherapy.
This study was designed to determine if fenbendazole (FZ) could prevent 5-fluorouracil (5-FU) resistance in colorectal cancer cells and patient-derived colon cancer organoids. FZ inhibited tumor growth and induced apoptosis in both SNU-C5 and 5-FU resistant SNU-C5/5-FUR cell lines. Moreover, FZ inhibited the phosphorylation of p53 and the activation of caspase-8 in 5-FU-resistant SNU-C5 cells. These results suggest that apoptosis and ferroptosis are responsible for the anticancer effects of fenbendazole in 5-FU-resistant cancer cells.
A video circulating on TikTok and Facebook claims that a dog dewormer called fenbendazole cures lung cancer. However, the claim is false and unproven. Several preclinical studies have investigated this class of drugs as cancer treatments, but they have yet to show any effectiveness in humans. In addition, a Canadian veterinarian who made the videos has been reprimanded by his professional association for promoting alternative medicines for dogs.
It kills cancer cells
Fenbendazole, which is a broad-spectrum anthelmintic, kills cancer cells in cell culture and animal models. It does so by inhibiting the polymerization of tubulin, which is a component of microtubules. Microtubules are a crucial part of the cell’s structure and provide shape and support. It also interferes with the cell’s ability to take up glucose, which cancer cells rely on for energy. This mechanism of action is similar to that of cytotoxic anticancer drugs, such as vinca alkaloids and taxanes.
In addition to its anti-tumor effects, fenbendazole induces apoptosis in colorectal cancer cells by inhibiting the mTOR pathway and increasing the activation of caspase-3. It also increases oxidative stress and induces autophagy and ferroptosis, which are both forms of cellular death. These mechanisms may help explain why fenbendazole is so effective against cancer cells.
While fenbendazole has shown promise as an anti-cancer drug, there is no evidence that it can cure cancer in humans. The claims of Joe Tippens, a US man who claimed to have cured his lung cancer by taking fenbendazole and other supplements, are not credible. While he did receive traditional cancer treatments, there are several other potential causes of his remission that aren’t being taken into account. Furthermore, he did not undergo a clinical trial that would be necessary to prove that fenbendazole works in human patients.
It prevents recurrence
The drug fenbendazole (methyl N-(6-phenylsulfanyl-1H-benzimidazol-2-yl) carbamate) is a broad-spectrum anthelmintic used to treat parasites in animals. Its anthelmintic activity is based on binding to b-tubulin microtubule subunits and disrupting their polymerization. Several studies have shown that this property can also be used to kill cancer cells.
These studies have shown that fenbendazole can prevent cancer cell proliferation in lab dishes and mice. However, there is no evidence that fenbendazole can cure cancer in humans. In fact, the claim in TikTok and Facebook videos is a misrepresentation of research findings. In his video, Jones cites an anecdotal story of Joe Tippens, a man who was treated for stage 4 lung cancer and claimed that he got rid of his cancer by taking fenbendazole. Tippens also received conventional cancer treatments, which may have contributed to his remission.
In a study, researchers found that fenbendazole can cause apoptosis and inhibit the growth of 5-fluorouracil-resistant colorectal cancer cells. It also triggers autophagy in these cells by reducing GPX4 expression. This results in enhanced caspase-3-dependent apoptosis and ferroptosis. The authors concluded that fenbendazole can be a useful supplemental therapy for patients with colorectal cancer resistant to chemotherapy.
It is safe
The drug fenbendazole is well known to be an effective antiparasitic. However, it can also suppress cancer cells in the laboratory (in vitro). Researchers have also discovered that benzimidazole carbamates, a group of drugs related to fenbendazole, can reduce breast cancer cell proliferation. These findings suggest that repurposing veterinary drugs to treat human cancer could save time and money. Development of new drugs requires several years, and repurposing existing drugs can shorten this process significantly.
Despite the fact that fenbendazole has been shown to slow tumor growth in cell culture and mice, there isn’t enough evidence that it can cure cancer patients. The nonprofit organization Cancer Research UK says that fenbendazole isn’t an effective cancer treatment, and it shouldn’t be used by patients without proper supervision.
Scientists think that fenbendazole works by stopping the proper growth of microtubules. These are cellular structures that give structure to all cells. But in cancer cells, these microtubules can take on an erratic, unstable shape that causes them to lose their structural integrity. When this happens, the cell stops growing and dies. By blocking the production of these microtubules, fenbendazole can stop the growth of cancer cells and prevent them from spreading. To test the effect of fenbendazole on tumors, scientists conducted three separate experiments. They analyzed the results by comparing tumor growth between groups. They also measured lung metastases at necropsy. fenbendazole for cancer